Weekly mRNA insider archive

19 min reading time RP Article 06 Nov ‘23

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Week 10

Liu M, Hu S, Yan N, Popowski KD, Cheng K. Inhalable extracellular vesicle delivery of IL-12 mRNA to treat lung cancer and promote systemic immunity. Nat Nanotechnol. 2024 Jan 11. doi: 10.1038/s41565-023-01580-3. Epub ahead of print. PMID: 38212521.

Zhang Z, Liu Q, Deng Z, Liu J, Li S, Hong M, Peng Y. Evaluating the Metabolic Basis of α-Gal A mRNA Therapy for Fabry Disease. Biology (Basel). 2024 Feb 8;13(2):106. doi: 10.3390/biology13020106. PMID: 38392324; PMCID: PMC10886685.

Mahony TJ, Briody TE, Ommeh SC. Can the Revolution in mRNA-Based Vaccine Technologies Solve the Intractable Health Issues of Current Ruminant Production Systems? Vaccines (Basel). 2024 Jan 31;12(2):152. doi: 10.3390/vaccines12020152. PMID: 38400135; PMCID: PMC10893269.

Week 08

Zhang H, Gao X, Sun Q, Dong X, Zhu Z, Yang C. Incorporation of poly(γ-glutamic acid) in lipid nanoparticles for enhanced mRNA delivery efficiency in vitro and in vivo. Acta Biomater. 2024 Feb 10:S1742-7061(24)00063-1. doi: 10.1016/j.actbio.2024.02.004. Epub ahead of print. PMID: 38342193.

Camperi J, Lippold S, Ayalew L, Roper B, Shao S, Freund E, Nissenbaum A, Galan C, Cao Q, Yang F, Yu C, Guilbaud A. Comprehensive Impurity Profiling of mRNA: Evaluating Current Technologies and Advanced Analytical Techniques. Anal Chem. 2024 Mar 5;96(9):3886-3897. doi: 10.1021/acs.analchem.3c05539. Epub 2024 Feb 20. PMID: 38377434; PMCID: PMC10918618.

Zhang Y, Chen C, Su M, Wang J, Li C, Yang X. Hydrophobization of Ribonucleic Acids for Facile Systemic Delivery and Multifaceted Cancer Immunotherapy. Nano Lett. 2024 Jan 31;24(4):1376-1384. doi: 10.1021/acs.nanolett.3c04507. Epub 2024 Jan 17. PMID: 38232332.

Week 07

Zhao Y, Gan L, Ke D, Chen Q, Fu Y. Mechanisms and research advances in mRNA antibody drug-mediated passive immunotherapy. J Transl Med. 2023 Oct 4;21(1):693. doi: 10.1186/s12967-023-04553-1. PMID: 37794448; PMCID: PMC10552228.

Wang S, Zhu Z, Li J. Pharmacokinetic Analyses of a Lipid Nanoparticle-Encapsulated mRNA-Encoded Antibody against Rift Valley Fever Virus. Mol Pharm. 2024 Jan 31. doi: 10.1021/acs.molpharmaceut.3c01016. Epub ahead of print. PMID: 38295278.

Tai W, Yang K, Liu Y, Li R, Feng S, Chai B, Zhuang X, Qi S, Shi H, Liu Z, Lei J, Ma E, Wang W, Tian C, Le T, Wang J, Chen Y, Tian M, Xiang Y, Yu G, Cheng G. A lung-selective delivery of mRNA encoding broadly neutralizing antibody against SARS-CoV-2 infection. Nat Commun. 2023 Dec 5;14(1):8042. doi: 10.1038/s41467-023-43798-8. PMID: 38052844; PMCID: PMC10697968.

Week 06

Scaria PV, Roth N, Schwendt K, Muratova OV, Alani N, Lambert LE, Barnafo EK, Rowe CG, Zaidi IU, Rausch KM, Narum DL, Petsch B, Duffy PE. mRNA vaccines expressing malaria transmission-blocking antigens Pfs25 and Pfs230D1 induce a functional immune response. NPJ Vaccines. 2024 Jan 6;9(1):9. doi: 10.1038/s41541-023-00783-y. PMID: 38184666; PMCID: PMC10771442.

Schober GB, Story S, Arya DP. A careful look at lipid nanoparticle characterization: analysis of benchmark formulations for encapsulation of RNA cargo size gradient. Sci Rep. 2024 Jan 29;14(1):2403. doi: 10.1038/s41598-024-52685-1. PMID: 38287070; PMCID: PMC10824725.

Zhao G, Xue L, Weiner AI, Gong N, Adams-Tzivelekidis S, Wong J, Gentile ME, Nottingham AN, Basil MC, Lin SM, Niethamer TK, Diamond JM, Bermudez CA, Cantu E, Han X, Cao Y, Alameh MG, Weissman D, Morrisey EE, Mitchell MJ, Vaughan AE. TGF-βR2 signaling coordinates pulmonary vascular repair after viral injury in mice and human tissue. Sci Transl Med. 2024 Jan 31;16(732):eadg6229. doi: 10.1126/scitranslmed.adg6229. Epub 2024 Jan 31. PMID: 38295183.

Week 05

Xue Y, Zhang Y, Zhong Y, Du S, Hou X, Li W, Li H, Wang S, Wang C, Yan J, Kang DD, Deng B, McComb DW, Irvine DJ, Weiss R, Dong Y. LNP-RNA-engineered adipose stem cells for accelerated diabetic wound healing. Nat Commun. 2024 Jan 25;15(1):739. doi: 10.1038/s41467-024-45094-5. PMID: 38272900; PMCID: PMC10811230.

Trivedi V, Yang C, Klippel K, Yegorov O, von Roemeling C, Hoang-Minh L, Fenton G, Ogando-Rivas E, Castillo P, Moore G, Long-James K, Dyson K, Doonan B, Flores C, Mitchell DA. mRNA-based precision targeting of neoantigens and tumor-associated antigens in malignant brain tumors. Genome Med. 2024 Jan 25;16(1):17. doi: 10.1186/s13073-024-01281-z. PMID: 38268001; PMCID: PMC10809449.

Han EL, Padilla MS, Palanki R, Kim D, Mrksich K, Li JJ, Tang S, Yoon IC, Mitchell MJ. Predictive High-Throughput Platform for Dual Screening of mRNA Lipid Nanoparticle Blood-Brain Barrier Transfection and Crossing. Nano Lett. 2024 Jan 23. doi: 10.1021/acs.nanolett.3c03509. Epub ahead of print. PMID: 38259198.

Week 04

Kubara K, Yamazaki K, Miyazaki T, Kondo K, Kurotaki D, Tamura T, Suzuki Y. Lymph node macrophages drive innate immune responses to enhance the anti-tumor efficacy of mRNA vaccines. Mol Ther. 2024 Jan 18:S1525-0016(24)00020-0. doi: 10.1016/j.ymthe.2024.01.020. Epub ahead of print. PMID: 38243602.

Tang C, Jing W, Han K, Yang Z, Zhang S, Liu M, Zhang J, Zhao X, Liu Y, Shi C, Chai Q, Li Z, Han M, Wang Y, Fu Z, Zheng Z, Zhao K, Sun P, Zhu D, Chen C, Zhang D, Li D, Ni S, Li T, Cui J, Jiang X. mRNA-Laden Lipid-Nanoparticle-Enabled in Situ CAR-Macrophage Engineering for the Eradication of Multidrug-Resistant Bacteria in a Sepsis Mouse Model. ACS Nano. 2024 Jan 23;18(3):2261-2278. doi: 10.1021/acsnano.3c10109. Epub 2024 Jan 11. PMID: 38207332.

Godbout K, Rousseau J, Tremblay JP. Successful Correction by Prime Editing of a Mutation in the RYR1 Gene Responsible for a Myopathy. Cells. 2023 Dec 22;13(1):31. doi: 10.3390/cells13010031. PMID: 38201236; PMCID: PMC10777931.

Week 03

Meyer BK, Nahas D, An M, Danziger A, Smith J, Patel M, Lin SA, Gleason A, Cox K, Capen R, Howe J, Bett A. Evaluation of luciferase and prefusion-stabilized F protein from respiratory syncytial virus mRNA/LNPs in pre-clinical models using jet delivery compared to needle and syringe. Vaccine X. 2023 Dec 9;16:100420. doi: 10.1016/j.jvacx.2023.100420. PMID: 38192619; PMCID: PMC10772402.

Gurung S, Timmermand OV, Perocheau D, Gil-Martinez AL, Minnion M, Touramanidou L, Fang S, Messina M, Khalil Y, Spiewak J, Barber AR, Edwards RS, Pinto PL, Finn PF, Cavedon A, Siddiqui S, Rice L, Martini PGV, Ridout D, Heywood W, Hargreaves I, Heales S, Mills PB, Waddington SN, Gissen P, Eaton S, Ryten M, Feelisch M, Frassetto A, Witney TH, Baruteau J. mRNA therapy corrects defective glutathione metabolism and restores ureagenesis in preclinical argininosuccinic aciduria. Sci Transl Med. 2024 Jan 10;16(729):eadh1334. doi: 10.1126/scitranslmed.adh1334. Epub 2024 Jan 10. PMID: 38198573; PMCID: PMC7615535.

Wang MM, Wappelhorst CN, Jensen EL, Chi YT, Rouse JC, Zou Q. Elucidation of lipid nanoparticle surface structure in mRNA vaccines. Sci Rep. 2023 Oct 5;13(1):16744. doi: 10.1038/s41598-023-43898-x. PMID: 37798336; PMCID: PMC10556076.

Week 02

Lowenthal MS, Antonishek AS, Phinney KW. Quantification of mRNA in Lipid Nanoparticles Using Mass Spectrometry. Anal Chem. 2024 Jan 8. doi: 10.1021/acs.analchem.3c04406. Epub ahead of print. PMID: 38189247.

Thelen JL, Leite W, Urban VS, O’Neill HM, Grishaev AV, Curtis JE, Krueger S, Castellanos MM. Morphological Characterization of Self-Amplifying mRNA Lipid Nanoparticles. ACS Nano. 2024 Jan 16;18(2):1464-1476. doi: 10.1021/acsnano.3c08014. Epub 2024 Jan 4. PMID: 38175970.

Yang M, Zhang Z, Jin P, Jiang K, Xu Y, Pan F, Tian K, Yuan Z, Liu XE, Fu J, Wang B, Yan H, Zhan C, Zhang Z. Effects of PEG antibodies on in vivo performance of LNP-mRNA vaccines. Int J Pharm. 2024 Jan 25;650:123695. doi: 10.1016/j.ijpharm.2023.123695. Epub 2023 Dec 9. PMID: 38081560.

Week 01

Escalona-Rayo O, Papadopoulou P, Slütter B, Kros A. Biological recognition and cellular trafficking of targeted RNA-lipid nanoparticles. Curr Opin Biotechnol. 2023 Dec 27;85:103041. doi: 10.1016/j.copbio.2023.103041. Epub ahead of print. PMID: 38154322.

Billingsley MM, Gong N, Mukalel AJ, Thatte AS, El-Mayta R, Patel SK, Metzloff AE, Swingle KL, Han X, Xue L, Hamilton AG, Safford HC, Alameh MG, Papp TE, Parhiz H, Weissman D, Mitchell MJ. In Vivo mRNA CAR T Cell Engineering via Targeted Ionizable Lipid Nanoparticles with Extrahepatic Tropism. Small. 2023 Dec 10:e2304378. doi: 10.1002/smll.202304378. Epub ahead of print. PMID: 38072809.

Wei T, Sun Y, Cheng Q, Chatterjee S, Traylor Z, Johnson LT, Coquelin ML, Wang J, Torres MJ, Lian X, Wang X, Xiao Y, Hodges CA, Siegwart DJ. Lung SORT LNPs enable precise homology-directed repair mediated CRISPR/Cas genome correction in cystic fibrosis models. Nat Commun. 2023 Nov 11;14(1):7322. doi: 10.1038/s41467-023-42948-2. PMID: 37951948; PMCID: PMC10640563.


Week 50

Mulroney TE, Pöyry T, Yam-Puc JC, Rust M, Harvey RF, Kalmar L, Horner E, Booth L, Ferreira AP, Stoneley M, Sawarkar R, Mentzer AJ, Lilley KS, Smales CM, von der Haar T, Turtle L, Dunachie S, Klenerman P, Thaventhiran JED, Willis AE. N1-methylpseudouridylation of mRNA causes +1 ribosomal frameshifting. Nature. 2023 Dec 6. doi: 10.1038/s41586-023-06800-3. Epub ahead of print. PMID: 38057663.

Zhang Y, Li S, Chu H, Li J, Lu S, Zheng B. A novel mRNA vaccine, TGGT1_278620 mRNA-LNP, prolongs the survival time in BALB/c mice with acute toxoplasmosis. Microbiol Spectr. 2023 Dec 1:e0286623. doi: 10.1128/spectrum.02866-23. Epub ahead of print. PMID: 38038457.

Kunkeaw N, Nguitragool W, Takashima E, Kangwanrangsan N, Muramatsu H, Tachibana M, Ishino T, Lin PJC, Tam YK, Pichyangkul S, Tsuboi T, Pardi N, Sattabongkot J. A Pvs25 mRNA vaccine induces complete and durable transmission-blocking immunity to Plasmodium vivax. NPJ Vaccines. 2023 Dec 14;8(1):187. doi: 10.1038/s41541-023-00786-9. PMID: 38092803.

Week 49

Pontes AP, van der Wal S, Ranamalla SR, Roelofs K, Tomuta I, Creemers LB, Rip J. Cell uptake and intracellular trafficking of bioreducible poly(amidoamine) nanoparticles for efficient mRNA translation in chondrocytes. Front Bioeng Biotechnol. 2023 Nov 10;11:1290871. doi: 10.3389/fbioe.2023.1290871. PMID: 38026902; PMCID: PMC10668025.

Bondue T, Berlingerio SP, Siegerist F, Sendino-Garví E, Schindler M, Baelde HJ, Cairoli S, Goffredo BM, Arcolino FO, Dieker J, Janssen MJ, Endlich N, Brock R, Gijsbers R, van den Heuvel L, Levtchenko E. Evaluation of the efficacy of cystinosin supplementation through CTNS mRNA delivery in experimental models for cystinosis. Sci Rep. 2023 Nov 28;13(1):20961. doi: 10.1038/s41598-023-47085-w. PMID: 38016974; PMCID: PMC10684520.

Rizvi F, Lee YR, Diaz-Aragon R, Bawa PS, So J, Florentino RM, Wu S, Sarjoo A, Truong E, Smith AR, Wang F, Everton E, Ostrowska A, Jung K, Tam Y, Muramatsu H, Pardi N, Weissman D, Soto-Gutierrez A, Shin D, Gouon-Evans V. VEGFA mRNA-LNP promotes biliary epithelial cell-to-hepatocyte conversion in acute and chronic liver diseases and reverses steatosis and fibrosis. Cell Stem Cell. 2023 Nov 20:S1934-5909(23)00392-2. doi: 10.1016/j.stem.2023.10.008. Epub ahead of print. PMID: 38029740.

Week 48

Zeng Y, Estapé Senti M, Labonia MCI, Papadopoulou P, Brans MAD, Dokter I, Fens MH, van Mil A, Sluijter JPG, Schiffelers RM, Vader P, Kros A. Fusogenic Coiled-Coil Peptides Enhance Lipid Nanoparticle-Mediated mRNA Delivery upon Intramyocardial Administration. ACS Nano. 2023 Nov 20. doi: 10.1021/acsnano.3c05341. Epub ahead of print. PMID: 37982378.

Miliotou AN, Georgiou-Siafis SK, Ntenti C, Pappas IS, Papadopoulou LC. Recruiting In Vitro Transcribed mRNA against Cancer Immunotherapy: A Contemporary Appraisal of the Current Landscape. Curr Issues Mol Biol. 2023 Nov 16;45(11):9181-9214. doi: 10.3390/cimb45110576. PMID: 37998753; PMCID: PMC10670245.

Patel, S.K., Billingsley, M.M., Mukalel, A.J., Thatte, A.S., Hamilton, A.G., Gong, N., El-Mayta, R., Safford, H.C., Merolle, M., Mitchell, M.J. (2024). Bile acid-containing lipid nanoparticles enhance extrahepatic mRNA delivery. Theranostics, 14(1), 1-16. doi: 10.7150/thno.89913.

Week 47

Reinhart AG, Osterwald A, Ringler P, Leiser Y, Lauer ME, Martin RE, Ullmer C, Schumacher F, Korn C, Keller M. Investigations into mRNA Lipid Nanoparticles Shelf-Life Stability under Nonfrozen Conditions. Mol Pharm. 2023 Nov 17. doi: 10.1021/acs.molpharmaceut.3c00956. Epub ahead of print. PMID: 37975733.

Hou Y, Lin S, Xia J, Zhang Y, Yin Y, Huang M, Xu Y, Yang W, Zhu Y. Alleviation of ischemia-reperfusion induced renal injury by chemically modified SOD2 mRNA delivered via lipid nanoparticles. Mol Ther Nucleic Acids. 2023 Oct 26;34:102067. doi: 10.1016/j.omtn.2023.102067. PMID: 38028193; PMCID: PMC10652142.

Brooks DL, Whittaker MN, Said H, Dwivedi G, Qu P, Musunuru K, Ahrens-Nicklas RC, Alameh MG, Wang X. A base editing strategy using mRNA-LNPs for in vivo correction of the most frequent phenylketonuria variant. HGG Adv. 2023 Oct 31:100253. doi: 10.1016/j.xhgg.2023.100253. Epub ahead of print. PMID: 37922902.

Week 46

Chehrazi-Raffle A, Budde LE, Pal SK. Boosting CAR T cells with anti-tumor mRNA vaccines. Nat Med. 2023 Nov 6. doi: 10.1038/s41591-023-02623-x. Epub ahead of print. PMID: 37932550.

Deal CE, Richards AF, Yeung T, Maron MJ, Wang Z, Lai YT, Fritz BR, Himansu S, Narayanan E, Liu D, Koleva R, Licht S, Hsiao CJ, Rajlic IL, Koch H, Kleyman M, Pulse ME, Weiss WJ, Doering JE, Lindberg SK, Mantis NJ, Carfi A, Plante OJ. An mRNA-based platform for the delivery of pathogen-specific IgA into mucosal secretions. Cell Rep Med. 2023 Oct 27:101253. doi: 10.1016/j.xcrm.2023.101253. Epub ahead of print. PMID: 37918405.

Tang X, Zhang J, Sui D, Yang Q, Wang T, Xu Z, Li X, Gao X, Yan X, Liu X, Song Y, Deng Y. Simultaneous dendritic cells targeting and effective endosomal escape enhance sialic acid-modified mRNA vaccine efficacy and reduce side effects. J Control Release. 2023 Nov 11;364:529-545. doi: 10.1016/j.jconrel.2023.11.008. Epub ahead of print. PMID: 37949317.

Week 45

Thatte AS, Hamilton AG, Nachod BE, Mukalel AJ, Billingsley MM, Palanki R, Swingle KL, Mitchell MJ. mRNA Lipid Nanoparticles for Ex Vivo Engineering of Immunosuppressive T Cells for Autoimmunity Therapies. Nano Lett. 2023 Oct 31. doi: 10.1021/acs.nanolett.3c02573. Epub ahead of print. PMID: 37906000.

Bolsoni J, Liu D, Mohabatpour F, Ebner R, Sadhnani G, Tafech B, Leung J, Shanta S, An K, Morin T, Chen Y, Arguello A, Choate K, Jan E, Ross CJD, Brambilla D, Witzigmann D, Kulkarni J, Cullis PR, Hedtrich S. Lipid Nanoparticle-Mediated Hit-and-Run Approaches Yield Efficient and Safe In Situ Gene Editing in Human Skin. ACS Nano. 2023 Nov 2. doi: 10.1021/acsnano.3c08644. Epub ahead of print. PMID: 37918441.

Antony JS, Birrer P, Bohnert C, Zimmerli S, Hillmann P, Schaffhauser H, Hoeflich C, Hoeflich A, Khairallah R, Satoh AT, Kappeler I, Ferreira I, Zuideveld KP, Metzger F. Local application of engineered insulin-like growth factor I mRNA demonstrates regenerative therapeutic potential in vivo. Mol Ther Nucleic Acids. 2023 Oct 16;34:102055. doi: 10.1016/j.omtn.2023.102055. PMID: 37928443; PMCID: PMC10622308.

Week 44

Zhang W, Pfeifle A, Lansdell C, Frahm G, Cecillon J, Tamming L, Gravel C, Gao J, Thulasi Raman SN, Wang L, Sauve S, Rosu-Myles M, Li X, Johnston MJW. The Expression Kinetics and Immunogenicity of Lipid Nanoparticles Delivering Plasmid DNA and mRNA in Mice. Vaccines (Basel). 2023 Oct 11;11(10):1580. doi: 10.3390/vaccines11101580. PMID: 37896985; PMCID: PMC10610642.

Häcker I, Rehling T, Schlosser H, Mayorga-Ch D, Heilig M, Yan Y, Armbruster PA, Schetelig MF. Improved piggyBac Transformation with Capped Transposase mRNA in Pest Insects. Int J Mol Sci. 2023 Oct 13;24(20):15155. doi: 10.3390/ijms242015155. PMID: 37894833; PMCID: PMC10606561.

Chan SH, Tirole L, Kneller D, Kelley TM, Dai N, Robb GB.  Co-transcriptional capping using an RNA capping enzyme-T7 RNA polymerase fusion protein. bioRxiv 2023.10.28.564488; doi: https://doi.org/10.1101/2023.10.28.564488

Week 43

Mackensen A, Haanen JBAG, Koenecke C, Alsdorf W, Wagner-Drouet E, Borchmann P, Heudobler D, Ferstl B, Klobuch S, Bokemeyer C, Desuki A, Lüke F, Kutsch N, Müller F, Smit E, Hillemanns P, Karagiannis P, Wiegert E, He Y, Ho T, Kang-Fortner Q, Schlitter AM, Schulz-Eying C, Finlayson A, Flemmig C, Kühlcke K, Preußner L, Rengstl B, Türeci Ö, Şahin U. CLDN6-specific CAR-T cells plus amplifying RNA vaccine in relapsed or refractory solid tumors: the phase 1 BNT211-01 trial. Nat Med. 2023 Oct 23. doi: 10.1038/s41591-023-02612-0. Epub ahead of print. PMID: 37872225.

Kitte R, Rabel M, Geczy R, Park S, Fricke S, Köhl U, Tretbar US. Lipid Nanoparticles (LNPs) outperform Electroporation in mRNA-based CAR T cell Engineering. Molecular Therapy – Methods & Clinical Development. 2023. Doi: 10.1016/j.omtm.2023.101139.

Tang Z, You X, Xiao Y, Chen W, Li Y, Huang X, Liu H, Xiao F, Liu C, Koo S, Kong N, Tao W. Inhaled mRNA nanoparticles dual-targeting cancer cells and macrophages in the lung for effective transfection. Proc Natl Acad Sci U S A. 2023 Oct 31;120(44):e2304966120. doi: 10.1073/pnas.2304966120. Epub 2023 Oct 25. PMID: 37878720; PMCID: PMC10622867.

Week 42

Zhang L, More KR, Ojha A, Jackson CB, Quinlan BD, Li H, He W, Farzan M, Pardi N, Choe H. Effect of mRNA-LNP components of two globally-marketed COVID-19 vaccines on efficacy and stability. NPJ Vaccines. 2023 Oct 11;8(1):156. doi: 10.1038/s41541-023-00751-6. PMID: 37821446; PMCID: PMC10567765.

Zhang X, Jozic A, Song P, Xu Q, Shi X, Wang H, Bishop L, Struthers HM, Rutledge J, Chen S, Xu F, Hancock MH, Zhu D, Sahay G, Chu CQ. mRNA vaccine against fibroblast activation protein ameliorates murine models of inflammatory arthritis. Rheumatol Immunol Res. 2023 Jul 22;4(2):90-97. doi: 10.2478/rir-2023-0013. PMID: 37818347; PMCID: PMC10561064.

Bähr-Mahmud H, Ellinghaus U, Stadler CR, Fischer L, Lindemann C, Chaturvedi A, Diekmann J, Wöll S, Biermann I, Hebich B, Scharf C, Siefke M, Roth AS, Rao M, Brettschneider K, Ewen EM, Şahin U, Türeci Ö. Preclinical characterization of an mRNA-encoded anti-Claudin 18.2 antibody. Oncoimmunology. 2023 Oct 16;12(1):2255041. doi: 10.1080/2162402X.2023.2255041. PMID: 37860278; PMCID: PMC10583639.

Week 41

Qiu K, Duan X, Mao M, Song Y, Rao Y, Cheng D, Feng L, Shao X, Jiang C, Huang H, Wang Y, Li H, Chen X, Wu S, Luo D, Chen F, Peng X, Zheng Y, Wang H, Liu J, Zhao Y, Song X, Ren J. mRNA-LNP vaccination-based immunotherapy augments CD8+ T cell responses against HPV-positive oropharyngeal cancer. NPJ Vaccines. 2023 Sep 29;8(1):144. doi: 10.1038/s41541-023-00733-8. PMID: 37773254; PMCID: PMC10542330.

Wang MM, Wappelhorst CN, Jensen EL, Chi YT, Rouse JC, Zou Q. Elucidation of lipid nanoparticle surface structure in mRNA vaccines. Sci Rep. 2023 Oct 5;13(1):16744. doi: 10.1038/s41598-023-43898-x. PMID: 37798336; PMCID: PMC10556076.

Friis KP, Gracin S, Oag S, Leijon A, Sand E, Lindberg B, Lázaro-Ibáñez E, Lindqvist J, Whitehead KA, Bak A. Spray dried lipid nanoparticle formulations enable intratracheal delivery of mRNA. J Control Release. 2023 Nov;363:389-401. doi: 10.1016/j.jconrel.2023.09.031. Epub 2023 Sep 30. PMID: 37741463.

Week 40

Kon E, Ad-El N, Hazan-Halevy I, Stotsky-Oterin L, Peer D. Targeting cancer with mRNA-lipid nanoparticles: key considerations and future prospects. Nat Rev Clin Oncol. 2023 Nov;20(11):739-754. doi: 10.1038/s41571-023-00811-9. Epub 2023 Aug 16. PMID: 37587254.

Tuma J, Chen YJ, Collins MG, Paul A, Li J, Han H, Sharma R, Murthy N, Lee HY. Lipid Nanoparticles Deliver mRNA to the Brain after an Intracerebral Injection. Biochemistry. 2023 Sep 20. doi: 10.1021/acs.biochem.3c00371. Epub ahead of print. PMID: 37729550.

Cheung M, Chang C, Rathnasinghe R, Rossignol E, Zhang Y, Ferrari A, Patel H, Huang Y, Sanchez Guillen M, Scalzo T, Lee C, Otten GR, Settembre EC, Music N, Palladino G, Wen Y. Self-amplifying mRNA seasonal influenza vaccines elicit mouse neutralizing antibody and cell-mediated immunity and protect ferrets. NPJ Vaccines. 2023 Oct 4;8(1):150. doi: 10.1038/s41541-023-00747-2. PMID: 37794051; PMCID: PMC10550923.

Week 39

Escalona-Rayo O, Zeng Y, Knol RA, Kock TJF, Aschmann D, Slütter B, Kros A. In vitro and in vivo evaluation of clinically-approved ionizable cationic lipids shows divergent results between mRNA transfection and vaccine efficacy. Biomed Pharmacother. 2023 Sep;165:115065. doi: 10.1016/j.biopha.2023.115065. Epub 2023 Jul 3. PMID: 37406506.

Chang DF, Court KA, Holgate R, Davis EA, Bush KA, Quick AP, Spiegel AJ, Rahimi M, Cooke JP, Godin B. Telomerase mRNA Enhances Human Skin Engraftment for Wound Healing. Adv Healthc Mater. 2023 Aug 24:e2302029. doi: 10.1002/adhm.202302029. Epub ahead of print. PMID: 37619534.

Ramirez F, Zambrano A, Hennis R, Holland N, Lakshmanaswamy R, Chacon J. Sending a Message: Use of mRNA Vaccines to Target the Tumor Immune Microenvironment. Vaccines (Basel). 2023 Sep 7;11(9):1465. doi: 10.3390/vaccines11091465. PMID: 37766141; PMCID: PMC10534833.

Week 38

Ma Y, Fenton OS. A Unified Strategy to Improve Lipid Nanoparticle Mediated mRNA Delivery Using Adenosine Triphosphate. J Am Chem Soc. 2023 Sep 13;145(36):19800-19811. doi: 10.1021/jacs.3c05574. Epub 2023 Sep 1. PMID: 37656876.

Sun J, Wang L, Matthews RC, Walcott GP, Lu YA, Wei Y, Zhou Y, Zangi L, Zhang J. CCND2 Modified mRNA Activates Cell Cycle of Cardiomyocytes in Hearts With Myocardial Infarction in Mice and Pigs. Circ Res. 2023 Sep;133(6):484-504. doi: 10.1161/CIRCRESAHA.123.322929. Epub 2023 Aug 11. PMID: 37565345; PMCID: PMC10529295.

Gunter HM, Idrisoglu S, Singh S, Han DJ, Ariens E, Peters JR, Wong T, Cheetham SW, Xu J, Rai SK, Feldman R, Herbert A, Marcellin E, Tropee R, Munro T, Mercer TR. mRNA vaccine quality analysis using RNA sequencing. Nat Commun. 2023 Sep 21;14(1):5663. doi: 10.1038/s41467-023-41354-y. PMID: 37735471; PMCID: PMC10514319.

Week 37

Zeng Y, Shen M, Pattipeiluhu R, Zhou X, Zhang Y, Bakkum T, Sharp TH, Boyle AL, Kros A. Efficient mRNA delivery using lipid nanoparticles modified with fusogenic coiled-coil peptides. Nanoscale. 2023 Sep 29;15(37):15206-15218. doi: 10.1039/d3nr02175k. PMID: 37671560.

Thran M, Pönisch M, Danz H, Horscroft N, Ichtchenko K, Tzipori S, Shoemaker CB. Co-administration of an effector antibody enhances the half-life and therapeutic potential of RNA-encoded nanobodies. Sci Rep. 2023 Sep 5;13(1):14632. doi: 10.1038/s41598-023-41092-7. PMID: 37670025; PMCID: PMC10480410.

Stewart-Jones GBE, Elbashir SM, Wu K, Lee D, Renzi I, Ying B, Koch M, Sein CE, Choi A, Whitener B, Garcia-Dominguez D, Henry C, Woods A, Ma L, Montes Berrueta D, Avena LE, Quinones J, Falcone S, Hsiao CJ, Scheaffer SM, Thackray LB, White P, Diamond MS, Edwards DK, Carfi A. Domain-based mRNA vaccines encoding spike protein N-terminal and receptor binding domains confer protection against SARS-CoV-2. Sci Transl Med. 2023 Sep 13;15(713):eadf4100. doi: 10.1126/scitranslmed.adf4100. Epub 2023 Sep 13. PMID: 37703353.

Week 36

Chan SH, Molé CN, Nye D, Mitchell L, Dai N, Buss J, Kneller DW, Whipple JM, Robb GB. Biochemical characterization of mRNA capping enzyme from Faustovirus. RNA. 2023 Nov;29(11):1803-1817. doi: 10.1261/rna.079738.123. Epub 2023 Aug 25. PMID: 37625853; PMCID: PMC10578482.

Di Grandi D, Dayeh DM, Kaur K, Chen Y, Henderson S, Moon Y, Bhowmick A, Ihnat PM, Fu Y, Muthusamy K, Palackal N, Pyles EA. A single-nucleotide resolution capillary gel electrophoresis workflow for poly(A) tail characterization in the development of mRNA therapeutics and vaccines. J Pharm Biomed Anal. 2023 Nov 30;236:115692. doi: 10.1016/j.jpba.2023.115692. Epub 2023 Sep 2. PMID: 37696189.

Shin H, Kang S, Won C, Min DH. Enhanced Local Delivery of Engineered IL-2 mRNA by Porous Silica Nanoparticles to Promote Effective Antitumor Immunity. ACS Nano. 2023 Sep 12;17(17):17554-17567. doi: 10.1021/acsnano.3c06733. Epub 2023 Aug 29. PMID: 37643221.

Week 35

Mae M. Lewis,  Melissa R. Soto,  Esther Y. Maier,  Steven D. Wulfe,  Sandy Bakheet,  Hannah Obregon,  Debadyuti Ghosh. Optimization of ionizable lipids for aerosolizable mRNA lipid nanoparticles. Bioeng Transl Med. 2023;e10580. doi:10.1002/btm2.10580.

Hamilton AG, Swingle KL, Joseph RA, Mai D, Gong N, Billingsley MM, Alameh MG, Weissman D, Sheppard NC, June CH, Mitchell MJ. Ionizable Lipid Nanoparticles with Integrated Immune Checkpoint Inhibition for mRNA CAR T Cell Engineering. Adv Healthc Mater. 2023 Aug 21:e2301515. doi: 10.1002/adhm.202301515. Epub ahead of print. PMID: 37602495.

Nakamae S, Miyagawa S, Ogawa K, Kamiya M, Taniguchi M, Ono A, Kawaguchi M, Teklemichael AA, Jian JY, Araki T, Katagami Y, Mukai H, Annoura T, Yui K, Hirayama K, Kawakami S, Mizukami S. Induction of liver-resident memory T cells and protection at liver-stage malaria by mRNA-containing lipid nanoparticles. Front Immunol. 2023 Aug 23;14:1116299. doi: 10.3389/fimmu.2023.1116299. PMID: 37680630; PMCID: PMC10482405.

Week 34

Douka S, Brandenburg LE, Casadidio C, Walther J, Garcia BBM, Spanholtz J, Raimo M, Hennink WE, Mastrobattista E, Caiazzo M. Lipid nanoparticle-mediated messenger RNA delivery for ex vivo engineering of natural killer cells. J Control Release. 2023 Sep;361:455-469. doi: 10.1016/j.jconrel.2023.08.014. Epub 2023 Aug 14. PMID: 37567506.

Yu F, Gong D, Yan D, Wang H, Witman N, Lu Y, Fu W, Fu Y. Enhanced adipose-derived stem cells with IGF-1-modified mRNA promote wound healing following corneal injury. Mol Ther. 2023 Aug 2;31(8):2454-2471. doi: 10.1016/j.ymthe.2023.05.002. Epub 2023 May 10. PMID: 37165618; PMCID: PMC10422019.

Zhu Z, Yang P. RNA repeats stall translation. Nat Chem Biol. 2023 Nov;19(11):1299-1300. doi: 10.1038/s41589-023-01404-4. PMID: 37592156.

Week 33

Breda L, Papp TE, Triebwasser MP, Yadegari A, Fedorky MT, Tanaka N, Abdulmalik O, Pavani G, Wang Y, Grupp SA, Chou ST, Ni H, Mui BL, Tam YK, Weissman D, Rivella S, Parhiz H. In vivo hematopoietic stem cell modification by mRNA delivery. Science. 2023 Jul 28;381(6656):436-443. doi: 10.1126/science.ade6967. Epub 2023 Jul 27. PMID: 37499029; PMCID: PMC10567133.

Popovitz J, Sharma R, Hoshyar R, Soo Kim B, Murthy N, Lee K. Gene editing therapeutics based on mRNA delivery. Adv Drug Deliv Rev. 2023 Sep;200:115026. doi: 10.1016/j.addr.2023.115026. Epub 2023 Jul 27. PMID: 37516409.

Kon E, Ad-El N, Hazan-Halevy I, Stotsky-Oterin L, Peer D. Targeting cancer with mRNA-lipid nanoparticles: key considerations and future prospects. Nat Rev Clin Oncol. 2023 Nov;20(11):739-754. doi: 10.1038/s41571-023-00811-9. Epub 2023 Aug 16. PMID: 37587254.

Week 32

Pomatto MAC, Gai C, Negro F, Massari L, Deregibus MC, De Rosa FG, Camussi G. Oral Delivery of mRNA Vaccine by Plant-Derived Extracellular Vesicle Carriers. Cells. 2023 Jul 11;12(14):1826. doi: 10.3390/cells12141826. PMID: 37508491; PMCID: PMC10378442.

Pine M, Arora G, Hart TM, Bettini E, Gaudette BT, Muramatsu H, Tombácz I, Kambayashi T, Tam YK, Brisson D, Allman D, Locci M, Weissman D, Fikrig E, Pardi N. Development of an mRNA-lipid nanoparticle vaccine against Lyme disease. Mol Ther. 2023 Sep 6;31(9):2702-2714. doi: 10.1016/j.ymthe.2023.07.022. Epub 2023 Aug 2. PMID: 37533256; PMCID: PMC10492027.

Lee J, Woodruff MC, Kim EH, Nam JH. Knife’s edge: Balancing immunogenicity and reactogenicity in mRNA vaccines. Exp Mol Med. 2023 Jul;55(7):1305-1313. doi: 10.1038/s12276-023-00999-x. Epub 2023 Jul 10. PMID: 37430088; PMCID: PMC10394010.

Week 23

Del Toro Runzer C, Anand S, Mota C, Moroni L, Plank C, van Griensven M, Balmayor ER. Cellular uptake of modified mRNA occurs via caveolae-mediated endocytosis, yielding high protein expression in slow-dividing cells. Mol Ther Nucleic Acids. 2023 May 20;32:960-979. doi: 10.1016/j.omtn.2023.05.019. PMID: 37305166; PMCID: PMC10250585.

Khare P, Edgecomb SX, Hamadani CM, Tanner EEL, S Manickam D. Lipid nanoparticle-mediated drug delivery to the brain. Adv Drug Deliv Rev. 2023 Jun;197:114861. doi: 10.1016/j.addr.2023.114861. Epub 2023 May 6. PMID: 37150326.

Dowdy SF. Endosomal escape of RNA therapeutics: How do we solve this rate-limiting problem? RNA. 2023 Apr;29(4):396-401. doi: 10.1261/rna.079507.122. Epub 2023 Jan 20. PMID: 36669888; PMCID: PMC10019367.

Week 19

Dolgin E. ‘Remarkable’ AI tool designs mRNA vaccines that are more potent and stable. Nature. 2023 May 2. doi: 10.1038/d41586-023-01487-y. Epub ahead of print. PMID: 37130908.

Chen X, Wang C, Lu Y. Tactics targeting circular mRNA biosynthesis. Biotechnol Bioeng. 2023 Jul;120(7):1975-1985. doi: 10.1002/bit.28410. Epub 2023 May 1. PMID: 37126367.

Week 17

Naidu GS, Yong SB, Ramishetti S, Rampado R, Sharma P, Ezra A, Goldsmith M, Hazan-Halevy I, Chatterjee S, Aitha A, Peer D. A Combinatorial Library of Lipid Nanoparticles for Cell Type-Specific mRNA Delivery. Adv Sci (Weinh). 2023 Jul;10(19):e2301929. doi: 10.1002/advs.202301929. Epub 2023 Apr 24. PMID: 37092557; PMCID: PMC10323619.

Pomatto MAC, Gai C, Negro F, Massari L, Deregibus MC, Grange C, De Rosa FG, Camussi G. Plant-Derived Extracellular Vesicles as a Delivery Platform for RNA-Based Vaccine: Feasibility Study of an Oral and Intranasal SARS-CoV-2 Vaccine. Pharmaceutics. 2023 Mar 17;15(3):974. doi: 10.3390/pharmaceutics15030974. PMID: 36986835; PMCID: PMC10058531.

Segel M, Lash B, Song J, Ladha A, Liu CC, Jin X, Mekhedov SL, Macrae RK, Koonin EV, Zhang F. Mammalian retrovirus-like protein PEG10 packages its own mRNA and can be pseudotyped for mRNA delivery. Science. 2021 Aug 20;373(6557):882-889. doi: 10.1126/science.abg6155. PMID: 34413232; PMCID: PMC8431961.

Week 16

Ren W, Duan S, Dai C, Xie C, Jiang L, Shi Y. Nanotechnology Lighting the Way for Gene Therapy in Ophthalmopathy: From Opportunities toward Applications. Molecules. 2023 Apr 15;28(8):3500. doi: 10.3390/molecules28083500. PMID: 37110734; PMCID: PMC10141718.

Chen P, He X, Hu Y, Tian XL, Yu XQ, Zhang J. Spleen-Targeted mRNA Delivery by Amphiphilic Carbon Dots for Tumor Immunotherapy. ACS Appl Mater Interfaces. 2023 Apr 26;15(16):19937-19950. doi: 10.1021/acsami.3c00494. Epub 2023 Apr 13. PMID: 37052212.

Week 15

He S, Gao B, Sabnis R, Sun Q. RNAdegformer: accurate prediction of mRNA degradation at nucleotide resolution with deep learning. Brief Bioinform. 2023 Jan 19;24(1):bbac581. doi: 10.1093/bib/bbac581. PMID: 36633966; PMCID: PMC9851316.

Shi D, Toyonaga S, Anderson DG. In Vivo RNA Delivery to Hematopoietic Stem and Progenitor Cells via Targeted Lipid Nanoparticles. Nano Lett. 2023 Apr 12;23(7):2938-2944. doi: 10.1021/acs.nanolett.3c00304. Epub 2023 Mar 29. PMID: 36988645; PMCID: PMC10103292.

Week 14

Xu X, Wang X, Liao YP, Luo L, Xia T, Nel AE. Use of a Liver-Targeting Immune-Tolerogenic mRNA Lipid Nanoparticle Platform to Treat Peanut-Induced Anaphylaxis by Single- and Multiple-Epitope Nucleotide Sequence Delivery. ACS Nano. 2023 Mar 14;17(5):4942-4957. doi: 10.1021/acsnano.2c12420. Epub 2023 Feb 28. PMID: 36853930; PMCID: PMC10019335.

Meulewaeter S, Nuytten G, Cheng MHY, De Smedt SC, Cullis PR, De Beer T, Lentacker I, Verbeke R. Continuous freeze-drying of messenger RNA lipid nanoparticles enables storage at higher temperatures. J Control Release. 2023 May;357:149-160. doi: 10.1016/j.jconrel.2023.03.039. Epub 2023 Mar 30. PMID: 36958400; PMCID: PMC10062427.

Yang Z, Li X, Gan X, Wei M, Wang C, Yang G, Zhao Y, Zhu Z, Wang Z. Hydrogel armed with Bmp2 mRNA-enriched exosomes enhances bone regeneration. J Nanobiotechnology. 2023 Apr 5;21(1):119. doi: 10.1186/s12951-023-01871-w. PMID: 37020301; PMCID: PMC10075167.

Week 13

Khandhar AP, Landon CD, Archer J, Krieger K, Warner NL, Randall S, Berube BJ, Erasmus JH, Sather DN, Staats HF. Evaluation of repRNA vaccine for induction and in utero transfer of maternal antibodies in a pregnant rabbit model. Mol Ther. 2023 Apr 5;31(4):1046-1058. doi: 10.1016/j.ymthe.2023.02.022. Epub 2023 Mar 24. PMID: 36965482; PMCID: PMC10124083.

Li B, Manan RS, Liang SQ, Gordon A, Jiang A, Varley A, Gao G, Langer R, Xue W, Anderson D. Combinatorial design of nanoparticles for pulmonary mRNA delivery and genome editing. Nat Biotechnol. 2023 Oct;41(10):1410-1415. doi: 10.1038/s41587-023-01679-x. Epub 2023 Mar 30. PMID: 36997680; PMCID: PMC10544676.

Xu X, Xia T. Recent Advances in Site-Specific Lipid Nanoparticles for mRNA Delivery. ACS Nanosci Au. 2023 Mar 30;3(3):192-203. doi: 10.1021/acsnanoscienceau.2c00062. PMID: 37360845; PMCID: PMC10288611.

Week 12

Zhong R, Talebian S, Mendes BB, Wallace G, Langer R, Conde J, Shi J. Hydrogels for RNA delivery. Nat Mater. 2023 Jul;22(7):818-831. doi: 10.1038/s41563-023-01472-w. Epub 2023 Mar 20. PMID: 36941391; PMCID: PMC10330049.

Patra T, Meyer K, Haga Y, Reagan EK, Weissman D, Ray R. Hepatitis C virus E1 and modified E2 delivered from an mRNA vaccine induces protective immunity. NPJ Vaccines. 2023 Mar 18;8(1):42. doi: 10.1038/s41541-023-00635-9. PMID: 36934116; PMCID: PMC10024013.

Luo J, Li S, Ye Z, Xu R, Yan H, Zhang J, Ye G, Chen L, Hu D, Teng X, Smith WA, Yakobson BI, Dai P, Nevidomskyy AH, He R, Zhu H. Evidence for Topological Magnon-Phonon Hybridization in a 2D Antiferromagnet down to the Monolayer Limit. Nano Lett. 2023 Mar 8;23(5):2023-2030. doi: 10.1021/acs.nanolett.3c00351. Epub 2023 Feb 16. PMID: 36797055.

Week 11

Kon E, Levy Y, Elia U, Cohen H, Hazan-Halevy I, Aftalion M, Ezra A, Bar-Haim E, Naidu GS, Diesendruck Y, Rotem S, Ad-El N, Goldsmith M, Mamroud E, Peer D, Cohen O. A single-dose F1-based mRNA-LNP vaccine provides protection against the lethal plague bacterium. Sci Adv. 2023 Mar 10;9(10):eadg1036. doi: 10.1126/sciadv.adg1036. Epub 2023 Mar 8. PMID: 36888708; PMCID: PMC9995031.

Gayet RV, Ilia K, Razavi S, Tippens ND, Lalwani MA, Zhang K, Chen JX, Chen JC, Vargas-Asencio J, Collins JJ. Autocatalytic base editing for RNA-responsive translational control. Nat Commun. 2023 Mar 11;14(1):1339. doi: 10.1038/s41467-023-36851-z. PMID: 36906659; PMCID: PMC10008589.

Bafaloukos D, Gazouli I, Koutserimpas C, Samonis G. Evolution and Progress of mRNA Vaccines in the Treatment of Melanoma: Future Prospects. Vaccines (Basel). 2023 Mar 13;11(3):636. doi: 10.3390/vaccines11030636. PMID: 36992220; PMCID: PMC10057252.

Week 10

Carter B, Huang P, Liu G, Liang Y, Lin PJC, Peng BH, McKay LGA, Dimitrakakis A, Hsu J, Tat V, Saenkham-Huntsinger P, Chen J, Kaseke C, Gaiha GD, Xu Q, Griffiths A, Tam YK, Tseng CK, Gifford DK. A pan-variant mRNA-LNP T cell vaccine protects HLA transgenic mice from mortality after infection with SARS-CoV-2 Beta. Front Immunol. 2023 Mar 9;14:1135815. doi: 10.3389/fimmu.2023.1135815. PMID: 36969239; PMCID: PMC10033589.

Ramos da Silva J, Bitencourt Rodrigues K, Formoso Pelegrin G, Silva Sales N, Muramatsu H, de Oliveira Silva M, Porchia BFMM, Moreno ACR, Aps LRMM, Venceslau-Carvalho AA, Tombácz I, Fotoran WL, Karikó K, Lin PJC, Tam YK, de Oliveira Diniz M, Pardi N, de Souza Ferreira LC. Single immunizations of self-amplifying or non-replicating mRNA-LNP vaccines control HPV-associated tumors in mice. Sci Transl Med. 2023 Mar 8;15(686):eabn3464. doi: 10.1126/scitranslmed.abn3464. Epub 2023 Mar 8. PMID: 36867683.

Week 9

Solodushko V, Fouty B. Terminal hairpins improve protein expression in IRES-initiated mRNA in the absence of a cap and polyadenylated tail. Gene Ther. 2023 Aug;30(7-8):620-627. doi: 10.1038/s41434-023-00391-4. Epub 2023 Feb 24. PMID: 36828937; PMCID: PMC9951143.

von der Haar T, Mulroney TE, Hedayioglu F, Kurusamy S, Rust M, Lilley KS, Thaventhiran JE, Willis AE, Smales CM. Translation of in vitro-transcribed RNA therapeutics. Front Mol Biosci. 2023 Feb 8;10:1128067. doi: 10.3389/fmolb.2023.1128067. PMID: 36845540; PMCID: PMC9943971.

Fang RH, Zhang L. Inhalable mRNA nanoparticles. Nat Mater. 2023 Mar;22(3):278-279. doi: 10.1038/s41563-023-01491-7. PMID: 36864158.

Week 8

Lu L, Ma W, Johnson CH, Khan SA, Irwin ML, Pusztai L. In silico designed mRNA vaccines targeting CA-125 neoantigen in breast and ovarian cancer. Vaccine. 2023 Mar 17;41(12):2073-2083. doi: 10.1016/j.vaccine.2023.02.048. Epub 2023 Feb 20. PMID: 36813666; PMCID: PMC10064809.

Week 7

Morse MA, Crosby EJ, Force J, Osada T, Hobeika AC, Hartman ZC, Berglund P, Smith J, Lyerly HK. Clinical trials of self-replicating RNA-based cancer vaccines. Cancer Gene Ther. 2023 Jun;30(6):803-811. doi: 10.1038/s41417-023-00587-1. Epub 2023 Feb 10. PMID: 36765179; PMCID: PMC9911953.

Greig JA, Chorazeczewski JK, Chowdhary V, Smith MK, Jennis M, Tarrant JC, Buza EL, Coughlan K, Martini PGV, Wilson JM. Lipid nanoparticle-encapsulated mRNA therapy corrects serum total bilirubin level in Crigler-Najjar syndrome mouse model. Mol Ther Methods Clin Dev. 2023 Feb 15;29:32-39. doi: 10.1016/j.omtm.2023.02.007. PMID: 36936447; PMCID: PMC10017950.

Sun H, Zhang Y, Wang G, Yang W, Xu Y. mRNA-Based Therapeutics in Cancer Treatment. Pharmaceutics. 2023 Feb 13;15(2):622. doi: 10.3390/pharmaceutics15020622. PMID: 36839944; PMCID: PMC9964383.

Xian H, Zhang Y, Yu C, Wang Y. Nanobiotechnology-Enabled mRNA Stabilization. Pharmaceutics. 2023 Feb 12;15(2):620. doi: 10.3390/pharmaceutics15020620. PMID: 36839942; PMCID: PMC9965532.

Week 6

Perkovic M, Gawletta S, Hempel T, Brill S, Nett E, Sahin U, Beissert T. A trans-amplifying RNA simplified to essential elements is highly replicative and robustly immunogenic in mice. Mol Ther. 2023 Jun 7;31(6):1636-1646. doi: 10.1016/j.ymthe.2023.01.019. Epub 2023 Jan 23. Erratum in: Mol Ther. 2023 Jul 5;31(7):2297. PMID: 36694464; PMCID: PMC10277886.

Liu GW, Guzman EB, Menon N, Langer RS. Lipid Nanoparticles for Nucleic Acid Delivery to Endothelial Cells. Pharm Res. 2023 Jan;40(1):3-25. doi: 10.1007/s11095-023-03471-7. Epub 2023 Feb 3. PMID: 36735106; PMCID: PMC9897626.

Week 5

Despic V, Jaffrey SR. mRNA ageing shapes the Cap2 methylome in mammalian mRNA. Nature. 2023 Feb;614(7947):358-366. doi: 10.1038/s41586-022-05668-z. Epub 2023 Feb 1. PMID: 36725932; PMCID: PMC9891201.

Week 4

You Y, Tian Y, Yang Z, Shi J, Kwak KJ, Tong Y, Estania AP, Cao J, Hsu WH, Liu Y, Chiang CL, Schrank BR, Huntoon K, Lee D, Li Z, Zhao Y, Zhang H, Gallup TD, Ha J, Dong S, Li X, Wang Y, Lu WJ, Bahrani E, Lee LJ, Teng L, Jiang W, Lan F, Kim BYS, Lee AS. Intradermally delivered mRNA-encapsulating extracellular vesicles for collagen-replacement therapy. Nat Biomed Eng. 2023 Jul;7(7):887-900. doi: 10.1038/s41551-022-00989-w. Epub 2023 Jan 12. PMID: 36635419.

Curreri A, Sankholkar D, Mitragotri S, Zhao Z. RNA therapeutics in the clinic. Bioeng Transl Med. 2022 Jul 6;8(1):e10374. doi: 10.1002/btm2.10374. PMID: 36684099; PMCID: PMC9842029.



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