LNP formulation

Any mRNA purchased from RIBOPRO can be formulated into lipid nano particles (LNPs) either with lipids being supplied by our customers or our proprietary lipids.

Our specialty is to formulate RNA in LNPs using the proprietary lipids and the unique formulation technology we develop at RIBOPRO.

Request LNP formulation
  • High mRNA delivery efficiency
  • Low toxicity and immunogenicity
  • Expanded control over bio-distribution

Custom LNP formulation

Our specialty is formulation in LNPs using the proprietary lipids and the unique microfluidic system we develop at RIBOPRO. Our LNPs display high mRNA delivery efficiency with low toxicity and immunogenicity, which is ideal for therapeutic use.

By using a novel core lipid system, our LNPs show a substantially lower bio-distribution to the liver, allowing the (active) targeting towards other organs. The ionizable lipids we developed have an extraordinary low toxicity and immunogenicity, while having a reasonably high endosomal escape activity.

Our services include:

  1. Producing nanoparticles of defined size (80-250nm, PDI <0.02)
  2. Buffer exchange (via dialysis)
  3. Dilution or concentration (0.01-2mg/ml mRNA, standard 0.1mg/ml)
  4. Quality control (size and PDI by DLS)
  5. Packaging and shipping



When ordering custom mRNA-LNP formulation, you have various choices and options to customize the product to your exact needs. Is your favorite option not listed? Please contact us and we are happy to discuss a custom project with you.

Choice Description
Formulation We have a list of standard LNP formulations ready to use based on your application.
Target delivery We can co-develop target delivery LNPs using our proprietary lipids.
Buffer Phosphate pH6-8, standard pH7.4
Citrate pH4-6
MES pH5.5-6.5
Other buffer upon request
Sterile filtering 0.22um (recommended)
QC assays Zèta-potential by DLS
Surface-charge by TNS
RNA-encapsulation by RiboGreen

How to get a quote?

Ready to take the next step? Getting a quote from us is quick and easy! Follow these simple steps to receive your personalized quote:

  1. Fill Out Our Form: Provide us with some basic details about your needs by filling out our user-friendly form. It only takes a few minutes!
  2. Tailored to You: Once we have your information, our Product Specialists will craft a customized quote specifically designed to meet your requirements.
  3. Get Your Quote: Receive your detailed quote in no time! We’ll send it directly to your email or give you a call, based on your preference.
  4. Review and Decide: Take your time to review your quote. Our Product Specialists are to answer any questions and provide further assistance to ensure you’re completely satisfied.
Why Choose to work with RIBOPRO?
  1. Fast and Easy Process: We value your time. Our streamlined process ensures you get your quote quickly and without hassle.
  2. Customized Quotes: No generic estimates here! We provide quotes that are tailored to your specific needs and preferences.
  3. Expert Assistance: Our experienced team is ready to guide you through every step, offering professional advice and support.
Get Started Now!

Fill out the form below and get your personalized quote today. If you prefer, you can also schedule a meeting with one of our Product Specialists. We’re excited to work with you!


Request LNP formulation

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We look forward helping you with the highest quality mRNA.