What will you achieve with mRNA? Life-changing medicines, vaccines and more made possible by the latest improvements in mRNA and LNP technology.
Therapeutic applications
Examples of what
can be done with mRNA
- Corona vaccines
- mRNA-based antibody therapeutics
- mRNA therapies for rare metabolic disorders
- Next-generation vaccines
- Immuno-oncology
- Discovering the function of genes and rescuing knock- downs/knock-outs
- (trans)Differentiation of (stem)-cells and treatment of organoids
- Targeted therapy for CKD
- Bone-regeneration
Corona vaccines
At the moment, the most well-known example of mRNA in the clinical setting is the use as vaccine against SARS-COV-2 (Corona virus). Before these vaccines, no mRNA medicine or vaccine had reached the market, mainly due to the mRNA technology being relatively new. Only recently, a combination of de-immunization of mRNA and improved mRNA-delivery technology, allowed effective use of mRNA.
These Corona vaccines have shown the robust immunological responses when expressing non-self proteins in a manner that mimics a viral infection (non-self proteins produced by autologous proteins). In addition, they proved that mRNA is a relatively easy technology to develop new vaccines with, because mRNA production is robust, regardless of sequence, whereas virus or protein production often require elaborate optimization and characterization.
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