What quality controls are performed on LNPs?

After the formulation and dialysis we measure the size distribution of the LNP sample via Dynamic Light Scattering (DLS), we also have the option to measure the zèta potential (electrokinetic potential) and encapsulation efficiency assay upon request. An internal control LNP is always formulated during a production run and allows us to validate the activity and toxicity of the LNPs on HeLa cells.